Anti-diarrhea Effect and Mechanism of Traditional Chinese Medicine
10.13422/j.cnki.syfjx.20192106
- VernacularTitle: 中药抗腹泻的药效作用及机制研究进展
- Author:
Ying CHEN
1
;
Shuo LI
2
;
Ping SU
2
;
Hai-jing ZHANG
2
;
Guang-ping ZHANG
2
;
Zu-guang YE
2
Author Information
1. College of Life Science, Liaoning Normal University, Dalian 116000, China
2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100075, China
- Publication Type:Research Article
- Keywords:
diarrhea;
traditional Chinese medicine;
action mechanism;
ion channel
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(21):203-211
- CountryChina
- Language:Chinese
-
Abstract:
Diarrhea is a common clinical digestive tract disease, and the second major cause of illness and death among children. At present, long-term irrational use of chemical drugs and antibiotics in the treatment of diarrhea will accelerate the emergence of drug resistance of intestinal pathogenic bacteria, and modern drug preparations and therapies cost very high, which therefore bring difficulties to clinical treatment. As a pure natural drug containing a variety of active ingredients, traditional Chinese medicine(TCM) has the advantages of low residue, low toxicity and low drug resistance. And the study shows that TCM preparations, single TCM and effective components of TCM have a unique efficacy in the treatment of diarrhea, which makes anti-diarrhea TCM become a hotspot in the research field of anti-diarrhea drugs. Therefore, through consultation of relevant Chinese and foreign literatures in recent years, this study summarizes relevant anti-diarrhea TCM, and systematically expounds the treatment of diarrhea with TCM in the aspects of regulating the balance of water and electrolyte, anti-inflammation, interfering with gastrointestinal hormone secretion, protecting intestinal mucosa, promoting intestinal repair. Specifically, because the excessive secretion and absorption of liquids and electrolytes by intestinal epithelial cells are two important factors in the pathogenesis of diarrhea, the reduction of intestinal fluid secretion and the promotion of intestinal fluid absorption become effective means for the treatment of diarrhea. This paper reviews the effects and mechanisms of TCM against diarrhea, in order to provide theoretical support for the study of the anti-diarrhea mechanism and the research and development of new drugs of TCM against diarrhea.
