Mechanism of Traditional Chinese Medicine Compound in Preventing and Treating Hepatocellular Carcinoma
10.13422/j.cnki.syfjx.20191921
- VernacularTitle: 中药复方防治肝癌作用机制研究进展
- Author:
Fei XU
1
;
Yang-li ZENG
1
;
Juan LI
1
;
Si CAI
1
;
Xi TANG
1
;
Zhi WANG
1
;
Li-hui XIAO
2
;
Shun-xiang LI
1
Author Information
1. Hunan Province Engineering Research Center of Bioactive Substance Discovery of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China
2. KAMP Medicine Co. Ltd., Changsha 410008, China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine compound;
prevention and treatment of liver cancer;
hepatocellular carcinoma;
inhibiting liver cancer tumors;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2019;25(24):196-204
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC) is the most common malignancy in the world. Although there is progress in HCC diagnosis and treatment, it is still the third leading cause of cancer death worldwide because it is not easily diagnosed early and the disease progresses quickly. China is a high-risk area for HCC, and the number of cases is high and on the rise. Its prevention and treatment is a pressing problem. At present, western medicine is still unclear about the complex pathogenesis and clinical treatment of HCC. There are still many shortcomings and huge challenges. Traditional Chinese medicine(TCM) has its unique advantages in the treatment of HCC. With an overall concept, it has unique therapeutic effect and fewer side effect on HCC,it can not only inhibit tumor growth, but also alleviate patients' clinical symptoms and improve their quality of life. Therefore, the study of the effect of TCM in treating HCC has attracted the attention from many clinicians and researchers. However, the chemical composition of TCM formula is complex, with many targets and huge network of pharmacodynamic mechanisms, which greatly limits the research on the development of clinical drugs for the Chinese medicine formula. In recent years, there have been achievements in the studies of anti-hepatocarcinoma efficacy and mechanism of action of Chinese medicine compound, which mainly focused on the compound's effect in inhibiting the proliferation of hepatocarcinoma cells, blocking cell cycle and inducing apoptosis and autophagy, inhibiting liver cancer cell invasion and metastasis, regulating the immune function, synergism and attenuation, and reversing the drug resistance. In this paper, domestic and foreign literatures on the above-mentioned pharmacodynamics and mechanism of anti-liver cancer of TCM compound were studied, analyzed, summarized and summarized. This paper briefly reviews the research progress of its anti-hepatocarcinoma mechanism, and provides scientific ideas and evidence for the future study of the anti-hepatocarcinoma mechanism of TCM compound and its rational clinical application.
