Application progress of arterial spin labeling technology in the field of cognitive dysfunction
10.3760/cma.j.issn.1673-4165.2019.11.009
- VernacularTitle: 动脉自旋标记技术在认知功能障碍性疾病领域的应用进展
- Author:
Liang YE
1
;
Jie ZHANG
1
;
Benyan LUO
2
;
Xiangming YE
1
Author Information
1. Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou 310014, China
2. Department of Neurology, the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China
- Publication Type:Review
- Keywords:
Cognition disorders;
Magnetic resonance imaging;
Spin labels;
Cerebrovascular circulation
- From:
International Journal of Cerebrovascular Diseases
2019;27(11):849-852
- CountryChina
- Language:Chinese
-
Abstract:
Arterial spin labeling (ASL) technology is a popular technique for evaluating and studying cerebral perfusion in recent years. It can sensitively detect the abnormal cerebral perfusion and effectively avoid the potential risks caused by exogenous contrast agents in other tests. Detection of the abnormal cerebral blood flow perfusion by ASL technology can early predict cognitive decline in normal elderly, explore the pathogeneses of mild cognitive dysfunction and Alzheimer's disease, and evaluate the cerebral blood flow around the ischemic focus and the establishment of collateral circulation in patients with aphasia after stroke. At the same time, it is verified that the decrease of cerebral blood flow perfusion is another precipitating factor of primary progressive aphasia except cortex atrophy. Although there are still some limitations, the ASL technology has a good prospect in the application of cognitive disorders.
