Updates on human equilibrative nucleoside transporter 1 in neoplastic diseases
10.3760/cma.j.issn.1673-4408.2019.11.013
- VernacularTitle: 人平衡核苷转运体1在肿瘤性疾病中的研究进展
- Author:
Dongxia XIONG
1
;
Feiqiu WEN
1
Author Information
1. Department of Hematology-Oncology , Children′s Hospital of Shenzhen, Affiliated to Zunyi Medical University, Shenzhen 518038, China
- Publication Type:Review
- Keywords:
Human equilibrative nucleoside transporter 1;
Nucleoside analogs;
Neoplasm
- From:
International Journal of Pediatrics
2019;46(11):827-830
- CountryChina
- Language:Chinese
-
Abstract:
The human equilibrative nucleoside transporter 1(hENT1)is a multi-integrated membrane protein that mediates the transport of nucleosides, nucleobases and nucleoside analogs.It is mainly distributed on the cell membrane in humans.hENT1 maintains the homeostasis of cells and the intracellular concentration of nucleoside drugs through facilitating diffusion, thereby affecting DNA and RNA synthesis, cell signaling, metabolic regulation and tumor chemotherapy.This article reviews the progress in the structure and function of hENT1, the distribution in tumor tissues, the nucleoside analogs response and the prognosis of neoplastic diseases.
