To explore the treatment mechanism of Wenpi decoction on ulcer colitis based on integrative pharmacology of traditional Chinese medicine platform
10.3760/cma.j.issn.1673-4246.2019.11.016
- VernacularTitle: 基于中药整合药理学平台的温脾汤治疗溃疡性结肠炎作用机制研究
- Author:
Honghua ZHANG
1
;
Shuling WANG
1
;
Bin YU
2
;
Yanan ZHANG
3
;
Xumin JI
4
Author Information
1. School of Medicine, Hangzhou Normal University, Hangzhou 310036, China
2. Basic Medical School, Jining Medical College, Jining 272067, China
3. Basic Medical School, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China
4. Basic Medical School, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China
- Publication Type:Journal Article
- Keywords:
Colitis, ulcerative;
Wen Pi Tang;
TCMIP;
Molecular mechanisms of pharmacological action (TCD)
- From:
International Journal of Traditional Chinese Medicine
2019;41(11):1225-1230
- CountryChina
- Language:Chinese
-
Abstract:
Objective:The active components and potential targets were predicted and confirmed to explore the possible mechanism of Wenpi decoction on ulcer colitis.
Methods:The traditional Chinese medicine integrated pharmacology platform (TCMIP) was used to construct the decoction-target-disease target network, and the key nodes were analyzed and screened. The function and pathway enrichment analysis were conducted to explore the biological processes, which Wenpi decoction may be involved in the treatment of ulcerative colitis.
Results:The study showed that there were 455 active ingredients and 3044 targets in Wenpi decoction. The 434 targets and multiple biological processes and metabolic pathways were involved, such as chemokine signaling pathways, estrogen signaling pathway, thyroid hormone signaling pathway, MAPK signaling pathway, and PI3K/Akt signaling pathway. These targets and pathways were consistent with the pathogenesis of ulcerative colitis reported in the literature. In addition, Wenpi decoction was potential to be applied in the treatment of tumor, endocrine and metabolic diseases.
Conclusions:This study provided a scientific basis for further studies on the mechanism of Wenpi decoction in the treatment for ulcer colitis.
