Relationship between plasma cytokine level and cognitive function in patients with stable schizophrenia
10.3760/cma.j.issn.1674-6554.2019.11.005
- VernacularTitle: 稳定期精神分裂症患者血浆细胞因子水平与认知功能的相关研究
- Author:
Wei FENG
1
;
Qiang JIA
2
;
Shuping TAN
3
;
Ting YU
3
;
Jia LI
3
;
Zhiren WANG
4
;
Fude YANG
5
;
Li TIAN
6
;
Yunlong TAN
5
Author Information
1. Peking University Sixth Hospital, Peking University Institute of Mental Health, Beijing 100191, China; The Fifth Clinical Department, Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China
2. The Sixth Clinical Department, Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China
3. Research Centre, Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China
4. Science and Technology Department, Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China
5. Hospital Office Department, Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China
6. Neuroscience Centre, University of Helsinki, Helsinki 0001496, Finland
- Publication Type:Clinical Trail
- Keywords:
Stable schizophrenia;
Cytokines;
Cognitive function
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(11):983-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between plasma cytokine level and cognitive function in patients with stable schizophrenia and explore the possible role of cytokine in the occurrence mechanism of cognitive impairment in them.
Methods:A total of 75 stable patients who met the mental disorder diagnostic criteria of DSM-IV (patient group) and 40 healthy people (control group) were included in the essay.The method of enzymelinked immunosorbent assay (ELISA) were used to detected the concentrations of plasma proinflammatory cytokines IL-1β, IL-8, TNF-α and IFN-γ as well as the anti-inflammatory cytokines IL-10 in all research objects.The MATRICS Consensus Cognitive Battery (MCCB) was used to assess the cognitive function of patients.The relationship between plasma cytokines and cognitive function of patients were analyzed when the differences of the plasma cytokines concentrations were compared between the patient group and the control group.
Results:(1)Compared with the control group, plasma IL-8 (2.80(2.13)pg/ml vs 0.23 (0.80)pg/ml), TNF-α (1.16(0.47)pg/ml vs 0.67(0.15)pg/ml) in the patient group showed statistically significant difference (P<0.01). (2)In the partial correlation analysis of plasma cytokines and cognitive functions in patients, TNF-α was negatively correlated with the attention/vigilance dimensions(r=-0.29, P=0.03).
Conclusion:Stable schizophrenia patients have some problems with cytokine level.There is a correlation between TNF-α level and attention/vigilance dimensions.What's more, cytokine level immunological abnormalities may play some role in the development of cognitive impairment occurrence in patients.
