Network Meta-analysis on the efficacy and safety of surgical resection and thermal ablations for hepatocellular carcinoma in China
10.3760/cma.j.issn.1007-8118.2019.11.007
- VernacularTitle: 我国肝细胞癌手术切除与热消融疗效和安全性比较的网络荟萃分析
- Author:
Kun XIONG
1
;
Liping ZHU
1
;
Yong LU
2
;
Bing SHEN
3
;
Di XUE
1
Author Information
1. School of Public Health, Fudan University; Key Laboratory of Health Technology Assessment, National Health Commission, Shanghai 200031, China
2. Department of Radiology, Ruijin Hospital Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
3. Transplantation Urology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
- Publication Type:Journal Article
- Keywords:
Carcinoma, hepatocellular;
Radiofrequency ablation;
Microwave ablation;
Surgical resection;
Meta-analysis
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(11):823-827
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the efficacy and safety of surgical resection and thermal ablations in patients with hepatocellular carcinoma in China using a network Meta-analysis.
Methods:References related to eligible randomized controlled studies (RCTs) were searched from China Biology Medicine, China National Knowledge Infrastructure(CNKI), PubMed, Embase and Cochrane Library from 1st January 2010 to 1st December 2017, and were selected according to the criteria. The 1-year, 3-year, and 5-year survival rates and incidence of serious complications were compared among surgical resection (SR), radiofrequency ablation (RFA), and microwave ablation(MWA) by network Meta-analysis based frequency and Bayesian methods.
Results:A total of 24 RCTs were included in this study. The results of surface under the cumulative ranking probabilities (SUCRA) showed that when all RCTs were included, the frequency model supported MWA had the highest 5-year overall survival rate (66.1%), while the Bayesian model supported SR had the highest 5-year overall survival rate (64.7%). When the tumor diameter of hepatocellular carcinoma was less than 5 cm and the liver function was Child-Pugh A/B, the frequency and Bayesian model both supported SR had the highest 5-year overall survival rate (89.1% and 88.3%, respectively). When all RCTs or RCTs were included with the tumor diameter less than 5 cm and liver function was Child-Pugh A/B, both the frequency and the Bayesian model supported RFA had the best safety (serious complications rate) (16.4%, 18.7%, 12.6 and 12.8%, respectively).
Conclusion:SR should be the first choice for early and small hepatocellular carcinoma, while RFA and MWA have their own indications.
