Impact of long-term antiviral therapy with Entecavir on renal function in elderly patients with chronic hepatitis B
10.3760/cma.j.issn.0254-9026.2019.11.016
- VernacularTitle: 长期恩替卡韦抗病毒治疗对老年慢性乙型肝炎患者肾脏功能的影响
- Author:
Li LIANG
1
;
Hongyi LI
;
Jiang REN
;
Min WANG
;
Guanhuan ZHANG
;
Yu WANG
;
Hong MA
Author Information
1. Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing 100050, China
- Publication Type:Journal Article
- Keywords:
Hepatitis B, chronic;
Antiviral agents;
Renal function
- From:
Chinese Journal of Geriatrics
2019;38(11):1258-1261
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the impact of long-term treatment with Entecavir(ETV)on renal function in elderly patients with chronic hepatitis B(CHB).
Methods:Elderly patients with CHB receiving ETV(0.5 mg/d)antiviral therapy who were followed up for 234 weeks in Beijing Friendship Hospital were retrospective analyzed.The estimated glomerular filtration rate(eGFR)(CKD-EPI creatinine formula)was used to evaluate renal function changes at baseline and 52, 104, 156, 208 and 234 weeks after treatment.
Results:A total of 40 included patients with CHB aged 60-81 years were enrolled, with baseline eGFR value(n=40) of (64.25±11.32)ml·min-1·1.73 m-2.The eGFR values at all time points after treatment were as following: (63.85±11.53)ml·min-1·1.73 m-2, (63.71±11.58)ml·min-1·1.73 m-2, (59.95±9.59)ml·min-1·1.73 m-2, (62.28±15.32)ml·min-1·1.73 m-2, (65.78±15.99)ml·min-1·1.73 m-2 at 52 weeks(40 cases), 104 weeks(40 cases), 156 weeks(38 cases), 208 weeks(36 cases)and 234 weeks(28 cases)after ETV treatment respectively.And the difference of eGFR values among all time points was not statistically significant(F=0.291, P=0.072). The results of the pairwise comparison showed that as compared with the baseline eGFR value, the eGFR values had no statistically significant difference at all time points after treatment(P>0.05). The baseline creatinine value in all 40 patients was(57.23±9.67)μmol/L.Creatinine values at 52 weeks(15 cases), 104 weeks(5 cases), 156 weeks(6 cases), 208 weeks(8 cases)and 234 weeks(6 cases)after ETV treatment, were(63.78±8.63)μmol/L, (67.86±11.21)μmol/L, (71.46±13.75)μmol/L, (68.22±8.99)μmol/L and(79.53±9.58)μmol/L respectively, with no significant difference(F=0.266, P=0.067). The results of the pairwise comparison showed that as compared with the baseline creatinine value, the creatinine values had no significant difference at all time points after ETV treatment(P>0.05).
Conclusions:ETV treatment has no effect on renal function in elderly patients with chronic hepatitis B.
