Botulinum Toxin Injection for the Treatment of Delayed Gastric Emptying Following Pylorus-Preserving Gastrectomy: an Initial Experience.
- Author:
Jung Hwan LEE
1
;
Chan Gyoo KIM
;
Young Woo KIM
;
Il Ju CHOI
;
Jong Yeul LEE
;
Soo Jeong CHO
;
Young Il KIM
;
Bang Wool EOM
;
Hong Man YOON
;
Keun Won RYU
Author Information
- Publication Type:Original Article
- Keywords: Surgery; Gastric stasis; Gastrectomy; Complications; Endoscopy; Botulinum toxins
- MeSH: Botulinum Toxins*; Diet; Endoscopy; Follow-Up Studies; Gastrectomy*; Gastric Emptying*; Gastroparesis; Humans; Medical Records; Postoperative Period; Recurrence
- From:Journal of Gastric Cancer 2017;17(2):173-179
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To report our experience of endoscopic botulinum toxin injection in patients who experienced severe delayed gastric emptying after pylorus-preserving gastrectomy (PPG). MATERIALS AND METHODS: We reviewed the medical records of 6 patients who received the botulinum toxin injection. They presented with severe delayed gastric emptying in the early postoperative period. Endoscopic botulinum toxin was administered as 4 injections of 25−50 IU into each of the 4 quadrants of the prepyloric area. RESULTS: All botulinum toxin injections were successful without any complications, enabling 5 patients to tolerate soft solid diets and one to tolerate a soft fluid diet within 10 days. The endoscopic criteria of 4 patients improved. Symptom recurrence caused 2 patients to undergo repeat injections that were successful. The median follow-up period was 27 months, and all patients could ingest normal regular diets at the last follow-up. CONCLUSIONS: Endoscopic botulinum toxin injection is a feasible treatment option for early delayed gastric emptying after PPG.
