The diagnostic value of combined specific IgG and specific IgE of Aspergillus fumigatus in allergic broncho pulmonary aspergillosis and severe asthma with fungal sensitization
10.3760/cma.j.issn.0578-1426.2019.11.009
- VernacularTitle: 联合检测烟曲霉特异性IgG和IgE对变应性支气管肺曲霉菌病与真菌致敏性重症支气管哮喘的诊断价值
- Author:
Haisheng HU
1
;
Huimin HUANG
;
Wenting LUO
;
Zhifeng HUANG
;
Qiqi HE
;
Baoqing SUN
Author Information
1. Department of Allergy, First Affiliated Hospital of Guangzhou Medical University, National Clinical Center for Respiratory Disease, Guangzhou Medical University, Guangzhou 510120, China
- Publication Type:Case Reports
- Keywords:
Aspergillosis, allergic bronchopulmonary;
Asthma;
Immunoglobulin IgG;
Immunoglobulin IgE
- From:
Chinese Journal of Internal Medicine
2019;58(11):826-828
- CountryChina
- Language:Chinese
-
Abstract:
This study aims to explore the diagnostic value of specific immunoglobulin E (sIgE) and specific immunoglobulin G (sIgG) of Aspergillus fumigatus in the diagnosis of allergic broncho-pulmonary aspergillosis (ABPA) and severe asthma with fungal sensitization (SAFS). A total of 17 ABPA patients and 14 SAFS patients were enrolled. The levels of sIgG [2 294.00 (1 527.00, 14 170.00) U/ml vs. 972.60 (650.90, 1 792.00) U/ml] and sIgE [8.77 (1.64, 16.85) kU/L vs. 1.04 (0.70, 2.05) kU/L] in ABPA patients were significantly higher than those in SAFS patients (P<0.05). Aspergillus fumigatus sIgG was strongly correlated with Aspergillus fumigatus sIgE (rs=0.797, P<0.001) in ABPA patients. When combined with Aspergillus fumigatus sIgG (>1 000.00 U/mL) and Aspergillus fumigatus sIgE (>1.00 kU/L), the sensitivity was 82.3% and specificity 78.6% for the differential diagnosis of ABPA and SAFS. It demonstrates the diagnostic value of Aspergillus fumigatus sIgG and sIgE.
