Research progress on reversion of multidrug resistance in tumor by cepharanthine
10.3760/cma.j.issn.1673-4246.2019.12.030
- VernacularTitle: 头花千金藤碱逆转肿瘤多药耐药作用机制研究进展
- Author:
Taiyang JI
1
;
Fuchao CHEN
;
Shan WANG
;
Changhu KE
;
Zhihao LI
Author Information
1. Department of pharmacy, Dongfeng Hospital Affiliated to Hubei University of Medicine/Hubei Key Laboratory of WudangLocal Chinese Medicine Research, , Shiyan 442000, China
- Publication Type:Review
- Keywords:
Cepharanthine;
Tumor;
Multidrug resistance;
Review
- From:
International Journal of Traditional Chinese Medicine
2019;41(12):1407-1410
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews the related literature on the reversal of multi-drug resistance in tumors by cepharanthine, and summarizes the reversal effects and mechanisms of multi-drug resistance in different tumors such as leukemia, liver cancer, ovarian cancer, breast cancer, esophageal cancer and colon cancer. Its reversal effect on multi-drug resistance of tumors is the result of a multi-channel, multi-link combination. The main mechanism is to inhibit membrane transporter function, affect enzyme transfer system, inhibit anti-apoptotic pathway activation and anti-apoptotic protein expression.
