The functional connection of central executive network in patients with depression after clinical cure
10.3760/cma.j.issn.1674-6554.2019.12.006
- VernacularTitle: 抑郁症临床治愈患者中央执行网络功能连接研究
- Author:
Jiaqi ZHONG
1
;
Zhenzhen WANG
1
;
Yang HAN
1
;
Changjun TENG
2
;
Hui WANG
2
;
Ning ZHANG
2
;
Hui MA
2
Author Information
1. School of Psychology, Nanjing Normal University, Nanjing 210097, China; Medical Psychology Department, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
2. Medical Psychology Department, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China
- Publication Type:Clinical Trail
- Keywords:
Central executive network;
Clinical cure;
Major depressive disorder;
Resting state function connection
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(12):1085-1090
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the changes in the functional connections of the central executive network in patients with depression after clinical cure.
Methods:Seventeen depression patients who met the clinical cure standard (patient group) and twenty-two healthy controls (control group) were selected.The baseline rs-fMRI data were collected from the healthy control group and the patient group respectively, and the rs-fMRI data in the patient group were collected again after 6 months.Compared the changes of central executive network function connection between the two groups.
Results:At baseline, there was a high functional connection in the left inferior parietal lobule(MNI: x, y, z=-39, -69, 33)and right insula(MNI: x, y, z=15, -45, 30) in the patient group compared with the control group.Compared with the baseline, there were high functional connections in part of the left inferior parietal lobe (MNI: x, y, z=-60, -48, 21) and the right dorsolateral prefrontal lobe (MNI: x, y, z=24, 18, 60), and low functional connections in part of the left inferior parietal lobe (MNI: x, y, z=-51, -69, 18) in patient group 6 months after clinical cure.Compared with the control group, there was a high functional connection in the right dorsolateral prefrontal lobe (MNI: x, y, z=45, 51, -6) and the right inferior parietal lobe (MNI: x, y, z=42, -48, 27) in patient group 6 months after clinical cure.
Conclusion:The functional connection of central executive network of depression patients has not been restored, and the related abnormality is not stable in six months after reaching the clinical cure standard.
