Role of inflammation in perioperative neurocognitive disorders and its therapeutic implication
10.3760/cma.j.issn.2095-4352.2019.12.028
- VernacularTitle: 围手术期神经认知障碍的炎症机制及治疗进展
- Author:
Yan XU
1
;
Chan CHEN
1
;
Chunling JIANG
1
;
Lulong BO
2
Author Information
1. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China
2. Faculty of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China
- Publication Type:Review
- Keywords:
Perioperative neurocognitive disorder;
Inflammation response;
Immune cell;
Therapeutic drug
- From:
Chinese Critical Care Medicine
2019;31(12):1559-1562
- CountryChina
- Language:Chinese
-
Abstract:
Perioperative neurocognitive disorder (PND) is one of the most common complications after operations in elderly patients. Occurrence of PND not only affects the quality of life but also increases the burden of medical care, as well as the post-operation disability and mortality rate. Previous studies have shown that the inflammatory response in central nervous system can lead to PND, however, its pathogenesis is undetermined. In this work, the role of neuro-inflammatory response and immune cell activation in the development of PND is reviewed, and the potential treatment is introduced, in order to provide insight for future research and clinical decision.
