Effect of dexmedetomidine combined with flurbiprofen axetil on postoperative pain and cognitive function of patients after thyroid gland surgery
10.3760/cma.j.issn.1008-6706.2020.03.003
- VernacularTitle: 右美托咪定联合氟比洛芬酯对甲状腺术后患者疼痛和认知功能的影响
- Author:
Zhiyu ZHANG
1
;
Zhipeng WU
2
;
Shanshan SUN
2
;
Juan REN
2
Author Information
1. Department of Traumatology, the People's Hosptial of Shouguang, Shouguang, Shandong 262700, China
2. Department of Anesthesiology, the People's Hosptial of Shouguang, Shouguang, Shandong 262700, China
- Publication Type:Journal Article
- Keywords:
Anesthesia and analgesia;
Dexmedetomidine;
Flurbiprofen;
Thyroid gland;
Surgical procedures, operative;
Pain, postoperative;
Cognition;
Controlled clinical trial
- From:
Chinese Journal of Primary Medicine and Pharmacy
2020;27(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of dexmedetomidine combined with flurbiprofen axetil on pain and cognitive function of patients after thyroidectomy.
Methods:A total of 80 patients with thyroid gland surgery in the People's Hosptial of Shouguang from January 2016 to December 2017 were selected and randomly divided into four groups according to the digital table: saline control group(C), dexmedetomidine group(D), flurbiprofen axetil group(F), dexmedetomidine combined with flurbiprofen axetil group(DF), with 20 casess in each group.The extubation time and wake-up time of the four groups were observed.The VAS scores were used to assess the analgesic effect after surgery, and the Riker sedation scale was used to assess postoperative anxiety.
Results:The extubation time of the C, D, F and FD group were (16.66±3.37)min, (24.63±2.80)min, (14.55±3.74)min, (26.22±3.45)min, respectively, which of group D and group DF was significantly longer than that in group C and group F(F= 4.59, P<0.01). The recovery time of group D[(17.98±2.54)min] and group DF[(17.84±3.63)min] was significantly longer than that of group F[(10.92±2.21) min] and group C[(9.95±2.16)min] (F=5.01, P<0.01). The VAS scores of group DF at 30 min, 3 h, 6 h and 24 h after recovery were significantly lower than those of group F and group D (F=4.53, 4.59, 4.61, 4.35, all P<0.01). The Rick sedation scores of C, D, F and FD groups were (5.28±1.81)points, (4.20±1.56)points, (4.24±2.01)points and (3.76±1.43)points, respetively, which of group DF was significantly lower than those of the other three groups(F=3.01, P<0.01). The MMSE scores of cognitive function in group DF at 3 h, 1 d and 3 d after surgery were significantly higher than those in group C (F=5.89, 4.95, 4.56, all P<0.01).
Conclusion:The combined use of dexmedetomidine and flurbiprofen axetil significantly reduces pain and relieves postoperative cognitive impairment after thyroid surgery.
