The association between mode of action and adverse outcome pathway and its application in risk assessment
10.3760/cma.j.issn.0253-9624.2020.02.020
- VernacularTitle: 毒作用模式和有害结局路径的关系及其在风险评估中的应用
- Author:
Hehai HUANG
1
;
Yongmei XIAO
Author Information
1. Department of Occupational and Environmental Health, Faculty of Preventive Medicine, School of PublicHealth, Sun Yat-Sen University, Guangzhou 510080, China
- Publication Type:Review
- Keywords:
Risk assessment;
Toxic actions;
Adverse outcome pathway
- From:
Chinese Journal of Preventive Medicine
2020;54(2):219-223
- CountryChina
- Language:Chinese
-
Abstract:
Risk assessment is a necessary technical means to protect human health and environmental safety. Traditional risk assessment based on toxicity data obtained from animal experiments was difficult to meet the need for risk assessment for a large number of chemicals due to the low throughput, long cycle, high cost and uncertainty of extrapolation to human exposure dose. The proposed risk assessment frameworks, the model of action (MOA) and the adverse outcome pathway (AOP), pointed the way for us to develop new and efficient evaluation methods. In this review, the basic concepts and contents of MOA and AOP, as well as the relationship between them, were introduced. Taking acrylamide (AA) as an example, this review briefly described the application of MOA/AOP framework in chemical risk assessment, so as to provide theoretical guidance for better application of MOA/AOP framework in chemical risk assessment.
