The emerging role of mitochondrial dysfunction in the pathogenesis and treatment of diabetic complications
10.3760/cma.j.issn.1000-6699.2020.02.014
- VernacularTitle: 线粒体功能障碍在糖尿病并发症发病机制及治疗中的研究进展
- Author:
Hua QU
1
;
Yi ZHENG
1
;
Xiaoli GONG
1
;
Hongting ZHENG
1
Author Information
1. Department of Endocrinology, the Second Affiliated Hospital of Army Medical University, Chongqing 400037, China
- Publication Type:Review
- Keywords:
Mitochondria;
Dysfunction;
Diabetes mellitus;
Complications
- From:
Chinese Journal of Endocrinology and Metabolism
2020;36(2):161-164
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial dysfunction plays an important role in the pathogenesis of diabetic complications, and more attention has been paid to the treatment strategies targeting mitochondrial function in these diseases. Our group has been devoted to exploring the relationship between mitochondrial dysfunction such as mitochondrial oxidative stress and energy metabolism, as well as various diabetic complications. This review highlighted recent progresses in the role of mitochondrial dysfunction in the pathogenesis of diabetic ulcer, diabetic nephropathy, diabetes complicated with nonalcoholic fatty liver and their correspondent molecular pathways, tried to explore the feasibility of targeting mitochondrial dysfunction in the treatment of these diseases.
