Expressions of tissue factor and vascular endothelial growth factor in diffuse large B-cell lymphoma and their clinical significances
10.3760/cma.j.issn.1009-9921.2020.01.010
- VernacularTitle: 组织因子及血管内皮生长因子在弥漫大B细胞淋巴瘤中的表达及其临床意义
- Author:
Yajun JIANG
1
;
Guihua ZHU
1
;
Yao HE
1
;
Xingxing CHAI
1
;
Xiaoyun YANG
1
;
Fanjing MENG
1
;
Wanchuan ZHUANG
1
Author Information
1. Department of Hematology, the Second People's Hospital of Lianyungang, Lianyungang 222006, China
- Publication Type:Journal Article
- Keywords:
Lymphoma, large B-cell, diffuse;
Vascular endothelial growth factors;
Tissue factor;
International prognostic index
- From:
Journal of Leukemia & Lymphoma
2020;29(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expressions of tissue factor (TF) and vascular endothelial growth factor (VEGF) in diffuse large B-cell lymphoma (DLBCL) and their clinical significances.
Methods:The clinical data of 80 cases of DLBCL diagnosed at the Second People's Hospital of Lianyungang from January 2010 to December 2017 were collected, and 30 cases of reactive hyperplasia of lymph node (RLN) were selected as the controls. The expressions of TF and VEGF in the two groups were detected by using immunohistochemical staining.
Results:The positive rate of TF and VEGF in the DLBCL group was higher than that in the RLN group [TF: 86.3% (69/80) vs. 50.0% (15/30) ; VEGF: 90.0% (72/80) vs. 53.3% (16/30) ; both P < 0.01]. And there was a positive correlation between the expression of TF and VEGF (r = 0.704, P < 0.05). There was no significant difference in the positive rates of TF and VEGF among the patients with different gender, age and Hans subtypes in DLBCL group (all P > 0.05). The positive rate of TF in DLBCL patients with B symptom, increased LDH, physical status grade ≥2, and extranodal lesion number >1 was higher (all P < 0.05). The positive rate of VEGF in patients with Ann Arbor stage Ⅲ-Ⅳ, B symptom, increased LDH, and extranodal lesion number >1 was higher (all P < 0.05). The positive rate of TF in international prognostic index (IPI) high-risk group was higher than that in low-risk group (P < 0.01); the positive rate of VEGF in IPI high-risk group and middle-high-risk group was higher than that in low-risk group (all P < 0.01). The expressions of TF (r = 0.491, P < 0.01) and VEGF (r = 0.529, P < 0.01) were positively correlated with IPI. The overall survival rates of TF and VEGF low-expression group were higher than those of TF and VEGF high-expression group (both P < 0.05).
Conclusion:The expressions of TF and VEGF are highly expressed in DLBCL, which is associated with the IPI. It can provide a reference value in evaluating prognosis of DLBCL.
