Research progress in effect of alendronate on healing of osteoporotic fracture
10.3760/cma.j.issn.1001-8050.2020.01.013
- VernacularTitle: 阿仑膦酸盐对骨质疏松性骨折愈合影响的研究进展
- Author:
Yajun WANG
1
;
Xiao CHEN
1
;
Xin ZHI
1
;
Jiacan SU
1
Author Information
1. Department of Traumatic Orthopedics, Changhai Hospital, Naval Medical University, Shanghai 200433, China
- Publication Type:Review
- Keywords:
Osteoporotic fractures;
Fracture healing;
Alendronate
- From:
Chinese Journal of Trauma
2020;36(1):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Fracture healing is a complex physiological process involving osteoblasts, osteoclasts and other cells and molecules. Typical fracture healing can be divided into four stages: inflammatory response, soft callus formation, hard callus formation, and bone remodeling. Osteoclasts play a leading role in hard callus formation and bone remodeling. Alendronate can inhibit osteoclast activity and bone loss in patients with osteoporosis, but it may also inhibit fracture healing. Therefore, whether alendronate can be used after osteoporotic fracture is controversial. In recent years, it has been found that alendronate can not affect the fracture healing, but also reduce the risk of secondary fracture and improve the prognosis of patients. In this article, the mechanism of alendronate and its effect on osteoporotic fracture healing by systemic and local use are reviewed, which can provide a reference for clinical selection of therapeutic drugs.
