Verticalization of frontal P axis on electrocardiography in patients with acute exacerbation of chronic obstructive pulmonary disease and asthma
10.3760/cma.j.issn.1671-7368.2020.01.006
- VernacularTitle: 慢性阻塞性肺疾病和哮喘急性发作患者心电图额面P电轴垂直化的观察研究
- Author:
Weihao LI
1
;
Huifang CAO
1
;
Ying FENG
1
;
Yuting PAN
1
;
Huili ZHU
2
Author Information
1. Department of Respiratory and Critical Care Medicine, Jing′an District Central Hospital of Shanghai, Shanghai 200040, China
2. Department of Respiratory and Critical Care Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China
- Publication Type:Journal Article
- Keywords:
Pulmonary disease, chronic obstructive;
Respiratory function test;
Electrocardiography;
Vectorcardiography;
Pulmonary emphysema
- From:
Chinese Journal of General Practitioners
2020;19(1):32-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of verticalization of frontal P axis on electrocardiagraphy (ECG) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and asthma.
Methods:Thirty five COPD patients and 20 asthma patients with acute exacerbation admitted in Jing′an District Central Hospital were enrolled and 20 health subjects served as a control group. The 12 lead ECG examination, pulmonary function test and high resolution CT (HRCT) scan of lung were performed. The P axis in ECG, pulmonary function and CT emphysema score were compared among three groups. The correlation of P axis verticalization with pulmonary function and CT emphysema score was analyzed.
Results:There were significant differences in P axis(F=24.36), FEV1/FVC(F=39.36), FEV1(F=28.82), FEV1%(F=30.64), FVC%(F=3.45), PEF%(F=13.22), RV/TLC(F=10.46) and total emphysema score (F=50.60) among the three groups (all P<0.01). P axis was positively correlated with age(r=0.229), total emphysema score(r=0.567), upper lung emphysema score(r=0.542), middle lung emphysema score(r=0.507), lower lung emphysema score(r=0.572)(all P<0.01), and negative correlation with body mass index(r=-0.491), cardiothoracic ratio (r=-0.396), FEV1/FVC(r=-0.609), FEV1(r=-0.389), FEV1%(r=-0.460), and PEF% (r=-0.419)(all P<0.01). Taking P axis>60 ° as cut-off value for screening COPD, the sensitivity was 0.933, specificity was 0.667, positive predictive value was 0.833 and negative predictive value was 0.857.
Conclusion:The verticalization of frontal P axis on ECG is significantly associated with obstructive ventilation disorder and CT emphysema score, which can be used as a preliminary screening index for COPD.
