Efficacy of pulmonary surfactant combined with caffeine citrate on neonatal respiratory distress syndrome treated with synchronized nasal intermittent positive pressure ventilation
10.3760/cma.j.issn.1673-4912.2019.09.007
- VernacularTitle: 肺表面活性物质联合枸橼酸咖啡因对同步鼻塞间歇正压通气治疗新生儿呼吸窘迫综合征疗效的影响
- Author:
Chang LIU
1
;
Shuqing ZHANG
2
;
Dongmei YUE
1
Author Information
1. Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang 110004, China
2. School of Pharmacy of China Medical University, Shenyang 110122, China
- Publication Type:Journal Article
- Keywords:
Neonatal respiratory distress syndrome;
Synchronized nasal intermittent positive pressure ventilation;
Pulmonary surfactant;
Caffeine citrate
- From:
Chinese Pediatric Emergency Medicine
2019;26(9):671-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical effects of pulmonary surfactant(PS) combined with caffeine citrate on neonatal respiratory distress syndrome(NRDS) treated with synchronized nasal intermittent positive pressure ventilation(SNIPPV).
Methods:We collected and analyzed 99 neonates who were diagnosed with NRDS and required SNIPPV treatment from January 2016 to June 2019 in NICU of Shengjing Hospital of China Medical University.According to the different treatment, they were divided into PS+ citrate caffeine combination group and control group.The control group(53 neonates)was treated by PS alone.The combination group(46 neonates)was treated with PS combined with caffeine citrate.The indexes of ventilator time, the time of using oxygen, length of hospital stay and complications were compared between the two groups.
Results:The indexes of ventilator time, the time of using oxygen and length of hospital stay of combination group were significantly shorter than those of the control group.The differences were statistically significant(P<0.05). However, the incidences of ventilator associated pneumonia, gastrointestinal dysfunction, arrhythmia and other complications were not significantly different between the two groups(P>0.05).
Conclusion:PS combined with caffeine citrate in the treatment of NRDS with SNIPPV could effectively improve the pulmonary function of infants.It could improve the neonatal survival rate and reduce complications.It is worth to be recommended.
