Clinical study of postoperative adjuvant radiotherapy and postoperative concurrent chemoradiotherapy for locally advanced hypopharyngeal squamous cell carcinoma
10.3760/cma.j.issn.1673-0860.2019.09.004
- VernacularTitle: 局部中晚期下咽鳞状细胞癌术后放疗与术后同步放化疗治疗的临床研究
- Author:
Kun LIU
1
;
Xinxin ZHANG
1
;
Mingbo LIU
1
;
Jialing WANG
1
;
Wenming WU
1
;
Deliang HUANG
1
;
Jiandong ZHAO
1
;
Lin MA
2
Author Information
1. Department of Otorhinolaryngology Head and Neck Surgery, Chinese People′s Liberation Army General Hospital, Medical School of Chinese People′s Liberation Army, Beijing 100853, China
2. Department of Radiotherapy, Chinese People′s Liberation Army General Hospital, Medical School of Chinese People′s Liberation Army, Bejing 100853, China
- Publication Type:Journal Article
- Keywords:
Neoplasm staging;
Carcinoma, squamous cell;
Radiotherapy;
Chemoradiotherapy, adjuvant;
Survival rate
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2019;54(9):662-669
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Using propensity score matching method (PSM) to investigate the clinical effect of postoperative adjuvant radiotherapy and postoperative concurrent chemoradiotherapy for locally advanced hypopharyngeal squamous cell carcinoma.
Methods:From July 2007 to July 2018,174 postoperative patients with locally advanced hypopharyngeal squamous cell carcinoma were enrolled in pre-PSM cohort, including 168 males and 6 females, the median age was 60 years old (ranged from 37 to 79 years old).Loco-regional control (LRC),progression-free survival (PFS) and overall survival (OS) were compared and analyzed between the patients treated with postoperative adjuvant radiotherapy and postoperative concurrent chemoradiotherapy (cisplatin was given in a dose of 80 mg/m2 on days 1, 22, and 43). After the propensity score matching (PSM), 61 sub-pairs of 122 patients were generated in post-PSM cohort. Survival rate were assessed with Kaplan-Meier method and Log-rank test.
Results:After the propensity score matching(PSM), 61 sub-pairs of 122 patients were generated in post-PSM cohort.The patients were followed up for 3-135 months, the median follow-up was 42 months. No significant differences in 3-year and 5-year LRC, PFS, OS were observed between the two groups (P>0.05) . For postoperative patients who had high-risk factors (extracapsular extension of nodal disease, and/or vascular embolism, and/or lymph node metastasis≥2, and/or positive surgical margin, and/or perineural infiltration),there were significant differences between the two groups in 3-year PFS (60.99% vs 84.49%,P<0.05), 5-year PFS (35.47% vs 56.97%,P<0.05) and 5-year LRC (41.02% vs 68.50%, P<0.05), but no significant difference was found in OS between the two groups (P>0.05).
Conclusion:Postoperative concurrent chemoradiotherapy was more efficacious than postoperative radiotherapy alone in terms of loco-regional control and PFS for high-risk postoperative patients with locally advanced hypopharyngeal squamous cell carcinoma.
