Clinicopathological analysis of 12 cases of children synovial sarcoma
10.3760/cma.j.issn.0529-5807.2019.09.008
- VernacularTitle: 儿童滑膜肉瘤12例临床病理学分析
- Author:
Yanfei LIU
1
;
Chao JIA
2
;
Meng ZHANG
2
;
Guangsheng CHEN
3
;
Nan ZHANG
2
;
Libing FU
2
;
Lin WANG
2
;
Lejian HE
2
Author Information
1. Department of Pathology, Beijing Children′s Hospital, Beijing 100045, China; Department of Pathology, Xi′an Children′s Hospital, Xi′an 710043, China
2. Department of Pathology, Beijing Children′s Hospital, Beijing 100045, China
3. Department of Pathology, Xi′an Children′s Hospital, Xi′an 710043, China
- Publication Type:Journal Article
- Keywords:
Sarcoma, synovial;
Immunohistochemistry;
Pathology, molecular
- From:
Chinese Journal of Pathology
2019;48(9):705-709
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate histopathological characteristics, and differential diagnoses of childhood synovial sarcoma.
Methods:HE staining, immunohistochemical staining and fusion gene detection by FISH were performed in 12 cases of synovial sarcoma in childhood at Beijing Children′s Hospital from 2016 to 2018.
Results:There were 6 cases of biphasic type, 1 case of monophasic epithelial type, 3 cases of monophasic spindle cell type and 2 cases of poorly differentiated synovial sarcomas. EMA, CKpan, bcl-2, CD99, TLE1 and CD34 immunostain positivities were observed in 10/12, 9/12, 12/12, 10/12, 10/12 and 0/12 cases respectively. Unique INI1 immunohistochemical staining was observed in 9/12 cases. SS18-SSX gene fusion was detected in 8 of 11 cases by FISH.
Conclusions:Synovial sarcoma is rare in children. Histological morphology combined with immunohistochemistry and FISH SS18-SSX fusion gene detection are important for the diagnosis and differential diagnosis of synovial sarcoma in children.
