Association between cord blood IgE and toddler atopic diseases
10.3760/cma.j.issn.1009-9158.2019.09.008
- VernacularTitle: 脐血IgE与儿童过敏性疾病的相关性研究
- Author:
Lin TANG
1
;
Wen YU
1
;
Xiaojing ZHANG
1
;
Chenchen ZHU
1
;
Qiaoling WU
1
;
Ye XIAO
1
;
Mei CAI
1
;
Bing WEI
1
;
Jun LUO
1
;
Li LI
2
;
Zhenhua TANG
1
Author Information
1. Department of Laboratory Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China
2. Department of Laboratory Medicine, Shanghai First People′s Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
- Publication Type:Journal Article
- Keywords:
Hypersensitivity;
Immunoglobulin E;
Fetal blood
- From:
Chinese Journal of Laboratory Medicine
2019;42(9):757-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between cord blood IgE level and allergic diseases (atopic dermatitis, food allergy, wheezing and allergic rhinitis) in 36 months old children and explore the susceptibility factors of allergy.
Methods:A cohort study was designed and Cord blood was collected during delivery of 779 women with full term, and the IgE level of the sample was detected by chemiluminescence immunoassay in Department of Laboratory Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine between October 1, 2012 and May 31, 2014. 638 children were followed up at the age of 36 months. The incidence of atopic dermatitis, food allergy, wheezing and allergic rhinitis were investigated by questionnaire, and the relationship between cord blood IgE level and allergic diseases in children was analyzed by multiple logistic regression.
Results:A total of 638 pregnant women and children were included in this study. The age of pregnant women was (29.7±3.3) years, and the IgE level in cord blood ranged from 0.1 to 8.43 IU/mL.In caesarean women, higher cord blood IgE was associated with increased risk of allergic dermatitis, wheezing and allergic rhinitis in children, OR=1.87, P<0.01; OR=1.86, P=0.01; OR=1.28, P=0.01; OR=1.98, P=0.01.
Conclusion:During cesarean section, the elevated IgE level of umbilical cord blood is correlated with the incidence of allergic diseases in children.
