Isocenter bilateral tangential fields combined with intensity-modulated radiotherapy for synchronous bilateral whole breast irradiation
10.3760/cma.j.issn.1004-4221.2019.09.009
- VernacularTitle: 同时性双侧乳腺癌保乳术后放疗技术和近期疗效分析
- Author:
Mingwei MA
1
;
Shulian WANG
2
;
Junjie MIAO
2
;
Yu TANG
2
;
Bo ZHAO
3
;
Shirui QIN
2
;
Jianghu ZHANG
2
;
Shunan QI
2
;
Siye CHEN
2
;
Yuchao MA
2
;
Xin LIU
2
;
Yexiong LI
2
Author Information
1. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021, China; Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China
2. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021, China
3. Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China
- Publication Type:Journal Article
- Keywords:
Breast neoplasm/adjuvant radiotherapy;
Radiation technique;
Short-term efficacy
- From:
Chinese Journal of Radiation Oncology
2019;28(9):677-681
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the dose characteristics and outcomes of a single isocenter bilateral tangential fields (IBTF) combined with intensity-modulated radiotherapy (IMRT) in bilateral breast radiotherapy (BBR).
Methods:Fourteen female patients with synchronous bilateral breast cancer (SBBC) after breast-conserving surgery (BCS) were enrolled in this study. All patients received BBR using IBTF combined with IMRT at a conventional (50 Gy/25f) or hypofractionated (43.5 Gy/15f) dose. For patients with invasive cancer, the additional tumor bed boost was given with sequential electron radiation or simultaneously photon IMRT. The coverage, uniformity and short-term clinical efficacy were evaluated.
Results:The number of the irradiation field was 8-11, including 4-7 intensity-modulated fields. The bilateral breast PTV dose coverage reached 95% in all plans. For the tumor bed, the mean dose coverage was (95.54±1.33)%(left) and (94.19±1.03)%(right) using photon, and (90.25±8.79)%(left) and (85.28±8.35)%(right) using electron. The average V20 of bilateral lungs was (16.69±3.90)%. The cardiac Dmean was 5.48 Gy. Three patients presented with grade Ⅱ acute skin toxicities. No ≥ grade Ⅱ pneumonitis was observed. No recurrence occurred with the median follow-up time of 30.1 months. Eleven patients showed excellent cosmetic results.
Conclusion:BBR using IBTF combined with IMRT is efficacious and safe for patients with SBBC after BCS.
