Mechanism of inflammatory reaction to vaccination and its effects on immunogenicity

VernacularTitle: 疫苗接种后炎症反应的发生机制及其对免疫原性的影响
Author: Chunlan ZHUANG ¹ ; Yingying SU ; Ting WU ; Jun ZHANG
Author Information

1. National Institute of Diagnostics and Vaccine Development in Infectious Diseases, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361100, China
Publication Type:Review
Keywords: Vaccine adverse reaction; Inflammation; Immunogenicity; Post-marketing surveillance
From: Chinese Journal of Microbiology and Immunology 2019;39(9):705-709
CountryChina
Language:Chinese
Abstract: Vaccination, one of the greatest inventions of mankind, prevents millions of people from infectious diseases and death each year. With the continuous improvement in immunization coverage, the safety of vaccines has attracted widespread attention. Common adverse reactions to vaccinations are mainly caused by inflammation, but the immune responses and biological damages following immunization are so complicated that the possible mechanisms have not been completely unveiled. Exploring the relationship between inflammation and immunogenicity after vaccination is of great significance for the monitoring and management of vaccines after marketing. This article reviewed the mechanism of inflammatory responses after vaccination and its potential impact on immunogenicity.