Clinical efficiency of orthotopic liver transplantation for advanced hepatic alveolar echinococcosis
10.3760/cma.j.issn.0254-1785.2019.09.009
- VernacularTitle: 肝移植治疗晚期肝泡型包虫病12例
- Author:
Aierken YILIYAER
1
;
Lingxiang KONG
;
Lei LI
;
Bo LI
;
Jiayin YANG
Author Information
1. Department of Liver Surgeryand Liver Transplantation Center, West China Hospital of Sichuan University.Chengdu 610041, China
- Publication Type:Clinical Trail
- Keywords:
Liver transplantation;
Hepatic alveolar echinococcosis;
Relapse
- From:
Chinese Journal of Organ Transplantation
2019;40(9):549-552
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the indications and clinical value of orthotropic liver transplantation(OLT)in patients with advanced hepatic alveolar echinococcosis(HAE).
Methods:The clinical data of 12 patients with advanced HAE who received OLT from January 2001 to December 2017 were retrospectively analyzed. Among them, there were 7 males and 5 females, the age ranged from 16~58 years(median 42 years). The preoperative hepatic functions of 12 patients were 2 Child-Pugh class A, 3 class B and 7 class C, and the median model for end-stage liver disease(MELD)score was 19.5(8~23).
Results:The mean time of OLT procedure and anhepatic phase in 12 patients were 456.25(456.25±44.98)min and 79.17(79.17±10.01)min respectively. The median intraoperative blood loss and hospital stay times were 1000 ml(600~4000 ml), and 29.5(15±58)days respectively. All the patients were followed-up for 0 months to 207 months. Among the 12 patients who underwent OLT, 2 recipients died of incurable infection of pulmonary infection on day 23 post-OLT, and multiple organ failure on day 32 post-OLT, respectively. One case developed lung metastasis 2 years after operation, and brain metastasis was found in the same patient after 4 years. The recurrence occurred 3 years after OLT in another patient, no evidence of HAE recurrence or extrahepatic metastasis was found in the remaining 8 patients.
Conclusions:OLT can provide patients with advanced HAE the best chance for long term disease-free and overall survival who lost the opportunity for radical hepatectomy.
