Correlation of thickened nuchal fold with fetal chromosomal abnormalities among 919 cases
10.3760/cma.j.issn.1003-9406.2019.09.005
- VernacularTitle: 919例胎儿颈后皮肤皱褶增厚与染色体异常的相关性
- Author:
Lishuang MA
1
;
Yan LUO
;
Limin RONG
;
Ping HUO
;
Jian GAO
;
Yali LI
Author Information
1. Department of Reproductive Genetics, Hebei Provincial People’s Hospital, Shijiazhuang, Hebei 050051, China
- Publication Type:Journal Article
- Keywords:
Nuchal fold;
Prenatal ultrasound examination;
Prenatal disgnosis;
Chromosomal abnormality
- From:
Chinese Journal of Medical Genetics
2019;36(9):874-876
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between fetal nuchal fold (NF) thickening and fetal chromosomal abnormality.
Methods:In total 919 pregnant women undergoing ultrasound examination were selected for interventional prenatal diagnosis in order to detect fetal chromosomal abnormality.
Results:The detection rate of chromosomal abnormality has significantly increased with NF thickness, advanced maternal age, presence of other ultrasound abnormalities (P<0.05). Trisomy 21 was the most common abnormality, and there was a prepondance for male fetuses.
Conclusion:Increased NF thickness is strongly associated with the risk of fetal chromosomal abnormalities, advanced maternal age and presence of additional ultrasound abnormalities.
