Relationship between serum CRTC3 and insulin resistance in patients with type 2 diabetes mellitus and abdominal obesity
10.3760/cma.j.issn.1000-6699.2019.09.007
- VernacularTitle: 2型糖尿病及腹型肥胖患者血清CRTC3水平与胰岛素抵抗的相关性研究
- Author:
Qiang WU
1
;
Meng LIU
2
;
Wencai KE
1
;
Xinmei HUANG
2
;
Fang SHEN
1
;
Jun LIU
2
Author Information
1. Department of Clinical Laboratory, Shanghai Fifth People′s Hospital, Fudan University, Shanghai 200240, China
2. Department of Endocrinology, Shanghai Fifth People′s Hospital, Fudan University, Shanghai 200240, China
- Publication Type:Clinical Trail
- Keywords:
Diabetes mellitus, type 2;
Abdominal obesity;
CRTC3;
Insulin resistance;
Adiponectin
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(9):761-764
- CountryChina
- Language:Chinese
-
Abstract:
To detect serum cAMP-responsive element-binding protein-regulated transcription coactivator 3 (CRTC3) level in subjects with type 2 diabetes mellitus and abdominal obesity and to investigate the relationship of serum CRTC3 level with glycolipid metabolism and insulin resistance. One hundred and seventy patients with type 2 diabetes (T2DM group) and 80 normal controls (NC group) were recruited in the study. They were divided into non-abdominal obesity (NAO) and abdominal obesity (AO) subgroup. Abdominal obesity was defined as waist circumference ≥90 cm in men and ≥85 cm in women. Body fat parameters were measured and body mass index, waist-to-hip ratio were determined. Fasting blood glucose (FBG), 2 h postload blood glucose (2hBG), lipids, HbA1C, fasting insulin, fasting C-peptide, CRTC3, and adiponectin were also detected. Insulin resistance and pancreas β cell function were assessed by modified homeostasis model assessment for insulin resistance (HOMA-IR) and β cell function (HOMA-β). Bivariate correlation analysis showed that serum CRTC3 level was positively correlated with waist circumference, body mass index, waist-to-hip ratio, systolic blood pressure, diastolic blood pressure, FBG, 2hBG, HbA1C, total cholesterol, triglyceride, fasting C-peptide, and HOMA-IR (P<0.05 or P<0.01), and was negatively correlated with high density lipoprotein-cholesterol, adiponectin, and HOMA-β (P<0.05). Multivariate linear regression analysis showed that waist-to-hip ratio, adiponectin, total cholesterol, FBG, and HOMA-IR were independently related to serum CRTC3 level (P<0.05 or P<0.01). Serum CRTC3 level was increased in patients with type 2 diabetes as well as in abdominal obesity, and was closely related with glycolipid metabolism, adiponectin, and insulin resistance.
