Progress of protein family containing coupling of ubiquitin conjugation to estrogen receptor degradation domain

VernacularTitle: 含有泛素偶联雌激素受体降解结构域蛋白家族的研究进展
Author: Wanchuan ZHUANG ¹ ; Qingyun WU ² ; Fanjin MENG ¹ ; Kailin XU ²
Author Information

1. Department of Hematology, the Second People's Hospital of Lianyungang, Lianyungang 222023, China
2. Blood Diseases Institute, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China
Publication Type:Review
Keywords: Leukemia; Cell proliferation; Coupling of ubiquitin conjugation to estrogen receptor degradation domain
From: Journal of Leukemia & Lymphoma 2019;28(10):634-637
CountryChina
Language:Chinese
Abstract: Coupling of ubiquitin conjugation to estrogen receptor degradation (CUE) domain containing protein, a newly discovered ubiquitin binding protein that contains CUE domain, plays an important role in the tumor formation, metastasis and drug resistance. Some researches have showed that CUE domain-containing protein 1 (CUEDC1) is associated with tumor lymphatic metastasis, and CUE domain-containing protein 2 (CUEDC2) is involved in the occurrence and development of solid tumors and leukemia by regulating cell cycle and signaling pathway activity. This review summarizes the CUE domain containing protein structure and the functions in the occurrence, progression, metastasis and drug-resistance of solid tumors and leukemia.