Signaling pathway of early brain injury after subarachnoid hemorrhage
10.3760/cma.j.issn.1673-4165.2019.10.014
- VernacularTitle: 蛛网膜下腔出血后早期脑损伤的信号通路
- Author:
Yipeng WANG
1
;
Xiaogang WANG
1
;
Geng GUO
1
;
Wen YANG
2
Author Information
1. Department of Neurosurgery, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
2. Department of Neurology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Review
- Keywords:
Subarachnoid hemorrhage;
Brain injuries;
Signal transduction
- From:
International Journal of Cerebrovascular Diseases
2019;27(10):791-795
- CountryChina
- Language:Chinese
-
Abstract:
Early brain injury (EBI) refers to the direct damage and secondary pathophysiological changes of brain tissue within 72 h after aneurysmal subarachnoid hemorrhage. Studies have shown that a variety of signaling pathways are involved in the mechanism of EBI, such as ecoxy chloropropane Kelch sample related protein-1 (Keap1)-nuclear factor E2 related factor 2 (Nrf2)-antioxidant response element (ARE) pathway, Toll-like receptor 4 (TLR4)/nuclear factor-κB pathway, phosphatidylinositol-3 kinase (PI3K)/protein kinase B (Akt) pathway. This article reviews the mechanisms of action of different signaling pathways involved in EBI.
