Study of tumor necrosis factor receptor superfamily 1B gene polymorphism in relation to the outcomes of HCV infection
10.3760/cma.j.issn.1007-3418.2019.10.011
- VernacularTitle: 肿瘤坏死因子受体超家族1B基因多态性与HCV感染结局的相关性
- Author:
Ping ZHU
1
;
Ming YUE
2
;
Qiong CHEN
3
;
Min YAO
4
;
Jingjing WU
5
;
Jianguo SHAO
6
;
Hong XUE
7
;
Yun ZHANG
8
;
Peng HUANG
5
;
Chunhui WANG
3
Author Information
1. Medical Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
2. Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
3. Eastern Theater Command Centers for Disease Control and Prevention, Nanjing 210002, China
4. Department of Immunology, Medical School of Nantong University, Nantong 226001, China
5. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
6. Department of Gastroenterology, the Nantong Third Affiliated Hospital of Nantong University, Nantong 226001, China
7. Fourth Ward, the Nantong Third Affiliated Hospital of Nantong University, Nantong 226001, China
8. Eastern Theater Command Centers for Disease Control and Prevention, Nanjing 210002, China; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
- Publication Type:Journal Article
- Keywords:
Hepatitis C virus;
Tumor necrosis factor receptor superfamily member 1B;
Gene polymorphism;
Chronicity
- From:
Chinese Journal of Hepatology
2019;27(10):793-798
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the tumor necrosis factor receptor superfamily 1B gene (TNFRSF1B) polymorphism in relation to the outcomes of hepatitis C virus (HCV) infection.
Methods:One thousand six hundred and forty-five cases without HCV infection, 545 cases with HCV clearance, and 783 cases with chronic HCV infection were enrolled. TaqMan probe method was used to investigate genotype rs1061622 (T > G) and rs1061624 (G > A). Two single nucleotide polymorphisms (SNPs) sites were genotyped and haplotypes were constructed to evaluate their relation with the outcome of HCV infection.
Results:Logistic regression analysis showed that there was no relation to the two SNPs with HCV infection susceptibility and chronicity (P > 0.05). Haplotype analysis showed that carrier TA had an increased susceptibility to HCV infection [adjusted odds ratio (OR) = 1.15, 95% confidence interval (CI): 1.01 to 1.30, P = 0.038)]. Carrier TA and GG haplotypes were conducive to chronic HCV infection (adjusted OR = 1.28, 95% CI: 1.08 to 1.53, P = 0.006; OR = 1.31, 95% CI: 1.03 to 1.66, P = 0.026).
Conclusion:The combinational effects of rs1061622 and rs1061624 in TNFRSF1B gene may increase the risk of HCV chronicity and infection.
