The value of combined detection of tumor biomarkers in the diagnosis and prognosis of patients with gallbladder carcinom
10.3760/cma.j.issn.1007-8118.2019.10.007
- VernacularTitle: 联合检测肿瘤标志物对胆囊癌诊断及患者预后的价值
- Author:
Bo YUAN
1
;
Xiaohui FU
2
;
Lei YIN
2
;
Wenlong YU
2
;
Jian LIU
2
;
Xiang WANG
2
;
Yongjie ZHANG
2
Author Information
1. Department of Hepatobiliary Surgery, Naval Characteristic Medical Center, Shanghai 200052, China
2. Second Department of Biliary Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Military Medical University, Shanghai 200438, China
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
CA19-9 antigen;
Carcinoembryonic antigen;
Diagnosis, differential;
Prognosis;
Tumor marker
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(10):746-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical value of serum tumor markers CA19-9, CA242, CEA, CA724 and CA125 in the diagnosis and prognosis of gallbladder carcinoma patients.
Methods:A retrospective analysis of the preoperative serum levels of CA19-9, CA242, CEA, CA724 and CA125 in 132 patients with gallbladder cancer admitted to Eastern Hepatobiliary Surgery Hospital from March 2009 to December 2013 for sensitivity comparison, Kaplan-Meier survival table was used for univariate survival analysis, and the log-rank method was compared for differences. The Cox regression model was used for multivariate survival analysis.
Results:The sensitivities of CA19-9, CA242, CA125, CEA and CA724 were 67.4%, 63.6%, 42.4%, 24.2% and 22.7%, respectively. There were no significant differences of the sensitivity between CA19-9 and CA242 (P>0.05). However, whether CA19-9 or CA242, there were significant differences of diagnostic sensitivity compared to CEA or CA724 or CA125 (all P<0.05). When CA19-9 was combined with CA125 or CEA or CA724, respectively, the sensitivity was improved, but there was no significant difference compared with CA19-9 alone (all P>0.05). Similarly, CA242 also has such a situation when compared with CA242 alone (all P>0.05). Univariate survival analysis showed there were statistically significant differences in CA19-9, CA242, and CEA (all P<0.05). Cox regression suggested that CA242 is an independent prognostic factor for gallbladder carcinoma. CA242 is closely related to histological grade of gallbladder carcinoma, lymph node metastasis and TNM staging.
Conclusions:CA19-9 and CA242 have definite value in the diagnosis of gallbladder carcinoma. CA242 is an independent prognostic factor for gallbladder carcinoma.
