Genetic Diversity and Exotoxin A Production of Group A Streptococci Causing Sepsis.
10.3346/jkms.2006.21.2.193
- Author:
Eun Ha KOH
1
;
Nam Yong LEE
;
Eui Chong KIM
;
Sunjoo KIM
Author Information
1. Department of Laboratory Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea. sjkim8239@hanmail.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Streptococcus pyogenes;
Group A Streptococci;
Sepsis;
Emm55 protein;
Streptococcus pyogenes;
Exotoxins;
Electrophoresis;
Gel;
Pulsed-field
- MeSH:
Virulence/genetics;
Variation (Genetics);
Streptococcus pyogenes/*genetics/*pathogenicity;
Streptococcal Infections/*etiology/microbiology;
Sepsis/*etiology/microbiology;
Middle Aged;
Membrane Proteins/*biosynthesis/*genetics;
Male;
Infant;
Humans;
Genotype;
Female;
Exotoxins/*biosynthesis/*genetics;
DNA, Bacterial/genetics/isolation & purification;
Child, Preschool;
Child;
Bacterial Proteins/*biosynthesis/*genetics;
Aged;
Adult;
Adolescent
- From:Journal of Korean Medical Science
2006;21(2):193-198
- CountryRepublic of Korea
- Language:English
-
Abstract:
The M protein and streptococcus pyrogenic exotoxin (SPE A) are important virulence factors in group A streptococci (GAS) infections. The emm types of GAS strains isolated from patients with sepsis were determined by sequencing the 5' N-terminus of the emm gene, encoding the M protein, and clonality analysis using pulsed-field gel electrophoresis. The presence of speA and production of SPE A were also examined. There were no predominant GAS clones. The emm genotypes were variable, and the most common genotype was emm13 (17.9%). The production prevalence of SPE A was 21.4%. The low mortality rate (7.1%) of GAS sepsis might be attributable to the low incidence of virulent strains such as emm1 (10.7%) and emm3 (7.1%), as well as to low production rate of SPE A.
