Correlation between WT1 gene polymorphism and multiple myeloma susceptibility
10.3872/j.issn.1007-385x.2019.02.014
- VernacularTitle:WT1基因多态性与多发性骨髓瘤易感的相关性
- Author:
LI Jing
1
;
WANG Lili
2
;
YANG Tao
3
;
WEN Li
4
;
XIAO Hua
5
;
LI Xiaohong
1
;
ZHANG Xiaohong
1
;
LI Yan
6
Author Information
1. Department of Hematology, Hebei Province Hospital of Chinese medicine
2. Department of Cardiology, Hebei Provincial People's Hospital,
3. Department of Urology Surgery, Hebei Provincial People's Hospital
4. Department of Hematology, Hebei Children's Hospital
5. Operation room, First Hospital of Hebei Medical University
6. Department of Hematology, Hebei Provincial People's Hospital
- Publication Type:Journal Article
- Keywords:
WT1 gene polymorphism;
regularities of distribution;
multiple myeloma;
susceptibility
- From:
Chinese Journal of Cancer Biotherapy
2019;26(2):225-229
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the correlation between WT1 gene polymorphism and multiple myeloma (MM) susceptibility in 168 patients. Methods: One hundred and sixty eight MM patients, who were hospitalized in our hospital and Hebei Provincial People's Hospital from January 2013 to December 2017, were researched in this study. There were 121 males (72%) and 47 females(28%) with a median age of 62.4 years old (36~83 years old). Polymorphism of WT1 gene of the samples was detected and analyzed by SSP-PCR and SBT-PCR. Results: Eleven WT1 alleles were detected in MM patients, WT1*010 and WT1*012 alleles occupied a higher frequency in MM group (WT1*010: OR=6.13, 95%CI:3.5~10.75, PC<0.000; WT1*012: OR=2.06, 95%CI:1.23~1.44, PC<0.051). STR genotype frequency of WT1*A5 markedly increased (OR=1.62, 95%CI:1.18~2.23, PC<0.05). Genotype frequency of WT1*010/010 also obviously increased (OR=6.28, 95%CI:1.81～21.76, PC<0.05). Conclusion: WT1 allele is highly polymorphic in MM patients and homozygote WT1*010/010 is a susceptible genotype of MM, indicating that the occurrence and development of MM are related to the polymorphism of WT1 gene.
- Full text:20190214.pdf
