Anti-oxidative effect of siwu decoction on aged mice
10.19485/j.cnki.issn2096-5087.2018.01.003
- VernacularTitle:四物汤对老龄小鼠肝组织抗氧化功能的影响
- Author:
De-Lei CAI
1
;
Cai-Ju XU
;
Wei LU
;
Jian-Yun FU
;
Qing CHEN
;
Yan-Hua SONG
Author Information
1. 浙江省疾病预防控制中心理化毒理所
- Keywords:
Siwu decoction;
Mice;
Antioxidant
- From:
Journal of Preventive Medicine
2018;30(1):9-11,15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the anti-oxidative function of siwu decoction.Methods Using aged mice model and setting three dose groups(0.58 g/kg BW, 1.17 g/kg BW, 3.50 g/kg BW), negative control group, after feeding four groups for 30 days with the lyophilized powder of the siwu decoction product, removing accessories, the content of lipid oxidation product malondialdehyde(MDA), glutathione(GSH)and protein carbonyl, the activity of superoxide dismutase(SOD)were tested. Results In the control group, the activity of SOD was(33.0±3.4)U/mgprot, and the content of GSH and protein carbonyl were(5.56±0.73)mg/gprot,(2.30±0.22)nmol/mgprot, respectively. Compared with the control group, the activity of SOD in the high dose group(39.2±6.3 U/mgprot)and the content of GSH in the medium and high dose group[(7.04±0.86) mg/gprot,(6.81±1.02)mg/gprot, respectively]was significantly higher(P<0.05); the content of protein carbonyl notably in the high dose group[(1.78±0.32)nmol/mgprot]significantly decreased(P<0.05). No obvious difference in the content of MDA were observed between each dose group and the control group (P>0.05). Conclusion Siwu decoction has obvious antioxidant effect on aged mice.
