An analysis on the risk factors of discontinued therapy among patients with multi -drug resistant pulmonary tuberculosis
- VernacularTitle:耐多药肺结核患者中断治疗的影响因素分析
- Author:
Ying PENG
1
;
Song-Hua CHEN
;
Bin CHEN
;
Ming-Wu ZHANG
;
Fei WANG
;
Tie-Niu HE
;
Lin ZHOU
;
Xiao-Meng WANG
Author Information
1. 浙江省疾病预防控制中心
- Keywords:
Muti -drug resistant;
Tuberculosis;
Therapy discontinued;
Adverse reactions;
Influencing factor
- From:
Journal of Preventive Medicine
2016;28(10):977-980
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the basic characteristics of the therapy discontinued patients with multi -drug resistant pulmonary tuberculosis (MDR -TB)and to find the causes of therapy discontinuing.Methods Using case -control study method,a questionnaire survey was conducted to analyze the causes of MDR -TB in the treatment of interruption,and to compare the characteristics with the treatment completed patients,and to analyze the risk factors of discontinued therapy among MDR -TB patients.Results The study included 45 cases of therapy discontinued MDR -TB patients,and 45 cases of MDR -TB patients who had completed the treatment as the control.Multivariate logistic regression analysis results showed that patients with over 65 years old(OR =8.69,95% CI =1.12,67.57),leak medication or drug withdrawal experience (OR =53.18,95% CI =5.90,479.27),were the risk factors of discontinued therapy(P <0.05).Patients with hospitalization for over 15 days was the protective factors for discontinued therpy(OR =0.09,95% CI =0.01,0.58), (P <0.05).Conclusion advanced age≥65 years old,low income,leak medication or drug withdrawal experience short hospitalization periods were related to the risk of MDR -TB patients therapy discontinuing.were the key targets for patient management in the future.
