Mechanism of Th2 related inflammatory factors in the pathogenesis of eczema
10.3969/j.issn.1006-0111.2019.01.003
- VernacularTitle:Th2相关炎症因子在湿疹发病中的作用机制
- Author:
Congcong ZHU
1
;
Huijun PAN
;
Quangang ZHU
Author Information
1. 上海中医药大学附属岳阳中西医结合医院药学研究室
- Keywords:
eczema;
inflammatory factor;
TSLP;
IL-4
- From:
Journal of Pharmaceutical Practice
2019;37(1):9-13
- CountryChina
- Language:Chinese
-
Abstract:
Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2immune response, and related inflammatory factors play an important role.Epithelial-derived factor like thymic stromal lymphopoietin and interleukin-33could trigger Th2immune imbalance and promote the secretion of type inflammatory factors such as interleukin-4, interleukin-5, and interleukin-13.These inflammatory factors will further induce eosinophilic granulocytosis and IgE formation.In this paper, the research progress of mechanism of type 2related inflammatory factors in eczema were reviewed, which provided the great significance for treatment.
