Synthesis and anti-oxidation activity of schisandrone derivatives
10.3969/j.issn.1006-0111.2018.02.004
- VernacularTitle:五味子酮衍生物的合成与抗氧化活性研究
- Author:
Pengru WANG
1
;
Wei LI
;
Xuemi PENG
;
Wei ZHENG
;
Liangjun GUO
;
Yongsheng JIN
Author Information
1. 第二军医大学学员旅
- Keywords:
schisandrone;
synthesis;
anti-oxidation
- From:
Journal of Pharmaceutical Practice
2018;36(2):112-115,135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To design and synthesize schisandrone derivatives for the therapy of disease like AD,and to meas-ure their anti-oxidation activity.Methods Ten compounds were synthesized,and seven of them were first reported.The influ-ence all the compounds on SOD from the mouse serum were measured to evaluate anti-oxidation activity.Structure-activity rela-tionship(SARs)were also discussed.Results Compounds 2,3,5 and 8 could increase the activity of SOD in mouse serum.Fur-thermore,Compounds 2,3 and 5 showed better activities than schisandrone.Conclusion Synthesized schisandrone derivatives showed anti-oxidation activity.The SARs demonstrated the carbonyl of C-1 position and the methyls of C-2 and 3 had no influ-ences to the anti-oxidant activity.
