Meropenem regimens based on the simple mathematical model of T>MIC for two-compartment model

VernacularTitle:基于T>MIC简易数学模型对二室模型的拓展适用性探讨美罗培南给药方案
Author: Yao CHEN ¹ ; Xiangqing SONG
Author Information

1. 湖南省娄底市中心医院药剂科
Keywords: times above MIC(T>MIC); carbapenem; meropenem; one-compartment model; two-compartment model
From: Journal of Pharmaceutical Practice 2017;35(4):341-345
CountryChina
Language:Chinese
Abstract: Objective To simplify the calculation of T>MIC and evaluate meropenem regimens based on the simple mathematical model of T>MIC reported in literature for two-compartment model.Methods Six meropenem regimens were designed according to the recommended dose with the infusion duration of 0.5 h and 3 h.Four different MIC susceptibility breakpoint of meropenem against clinical microbiologic flora were used to formulate different T>MIC.Each T>MIC was calculated by both the simple and two-compartment model of T>MIC.Meropenem regimens were evaluated for different bacterial infections based on the simple model of T>MIC with 40%~100% of the T>MIC% as the target.The t-test suggested no significant difference between the pairs of T>MIC calculated by the two models.Results and Conclusion Simple model of T>MIC can replace the two-compartment model.Meropenem regimens can be optimized based on this simple model of T>MIC conveniently and quickly.