Protective effects of the total bakkenolides from Petasites .tricholobus on high al-titude hypoxia
10.3969/j.issn.1006-0111.2017.02.005
- VernacularTitle:蜂斗菜总内酯对动物高原缺氧保护作用的研究
- Author:
Yeqing WANG
1
;
Yaoyu XIE
;
Hui ZHANG
;
Hong WU
;
Meili GUO
Author Information
1. 第二军医大学药学院生药学教研室
- Keywords:
P.tricholobus;
total bakkenolides;
high altitude;
anti-hypoxia;
hypobaric hypoxia
- From:
Journal of Pharmaceutical Practice
2017;35(2):116-120,125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of the total bakkenolides from P .tricholobus on high altitude hy-poxia .Method Normobaric hypoxia model and acute hypobaric hypoxia model in mice ,hypobaric hypoxia model in rats were established for this study .Survival time and survival rate of mice were recorded .The level of blood sugar and glycogen ,adeno-sine triphosphate (ATP) ,lactic acid (LD) ,lactic dehydrogenase (LDH) were detected in different organs of rats .Results The total bakkenolides significantly prolonged the survival time of mice in normobaric hypoxia model and reduced the death rate of mice in acute hypobaric hypoxia model .The total bakkenolides suppressed blood sugar level in rats and increased the glyco-gen level in rat liver ,skeletal muscle and myocardium .It also elevated the ATP content in rat brain ,liver ,skeletal muscle and myocardium .Meanwhile ,the content of LD in plasma ,skeletal muscle ,myocardium and LDH level in myocardium were re-duced .Conclusion The total bakkenolides from P .tricholobus have protective effect on normobaric hypoxia model and acute hypobaric hypoxia model in mice as well as hypobaric hypoxia model in rats .Its anti-hypoxia efficacy at high altitude may relate to the increased blood sugar ,glycogen ,and ATP level and reduced LD ,LDH level in major organs .
