A Meta-analysis of Bifidobacterium viable triple capsule on Helicobacter py lori eradication during clinical therapy
10.3969/j.issn.1006-0111.2016.04.025
- VernacularTitle:双歧杆菌三联活菌胶囊辅助根除幽门螺杆菌感染临床疗效的荟萃分析
- Author:
Liu LIU
1
;
Sujuan FEI
Author Information
1. 徐州医学院,江苏徐州,221002
- Keywords:
Bifidobacterium viable triple capsule;
Hp eradication rate;
Meta-analysis
- From:
Journal of Pharmaceutical Practice
2016;34(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effecacy of Bifidobacterium viable triple capsule on anti-Helicobacter pylori (Hp) treatment and its adverse reactions during eradication therapy .Methods T rials on the effect of Bifidobacterium viable triple capsule on Hp eradication were analyzed by Meta-analysis with the software Stata 12 .0 for comprehensive quantitative analysis of its clinical efficacy and adverse reactions during treatment .Results Eight randomly controlled trials (n=114 4) were includ-ed .Pooled Hp eradication rates were 85.91% and 69 .21% for patients with and without Bifidobacterium viable triple capsule respectively ,with the odds ratio (OR) being 3 .07 (95% CI=2 .25~4 .19 ,test for overall effect Z= 7 .08 , P<0 .01);the occurrences of total adverse reactions were 7 .58% and 20.87% respectively ,with the summary OR being 0 .42 (95% CI=0 .29~0 .61 ,test for overall effect Z= 4 .48 , P< 0 .01) .The difference of the two groups was statistically significant . Conclusion Current evidence shows that Bifidobacterium viable triple capsule could increase eradication rate of anti-Hp treat-ment and improve adverse reactions during therapy .
