Research progress of inhibitors of peptides and peptidomimetic acting on P 53-MDM2 i nte rf ace

VernacularTitle:P53-MD M2界面的肽类及拟肽类抑制剂的研究进展
Author: Xiang LI ¹ ; Yan ZOU ; Maocheng WU ; Ting HUANG ; Honggang HU ; Qiuye WU
Author Information

1. 第二军医大学药学院有机化学教研室
Keywords: P53-MDM2; peptide; inhibitor
From: Journal of Pharmaceutical Practice 2015;(6):494-497,512
CountryChina
Language:Chinese
Abstract: Tumor diseases have attracted great attention of the society because of the increasing morbidity in recent years .To inhibit the P53-MDM2 interaction has become an important target for design of cancer drug ,and a lot of peptide and small molecule inhibitors have been found with various kinds of drug screening and research tools .This paper summarized the recent progress of the peptide and peptidomimetic inhibitors of P53-MDM2 at home and abroad lately .