Research progress in mitochondria-targeted antioxidants
10.3969/j.issn.1006-0111.2015.01.001
- VernacularTitle:线粒体靶向抗氧化剂研究进展
- Author:
Pengcheng FAN
1
;
Yue GE
;
Wei JIANG
;
Linlin JING
;
Huiping MA
;
Zhengping JIA
Author Information
1. 兰州军区兰州总医院药剂科
- Keywords:
mitochondria-targeted;
antioxidant;
reactive oxygen species;
oxidative stress
- From:
Journal of Pharmaceutical Practice
2015;(1):1-4,8
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria are the main places of cellular respiration as well as the citric acid cycle and oxidative phospho‐rylation .It plays an important role in controlling the life and death of cells .Mitochondrial dysfunction leads to a series of human diseases such as ischemia‐reperfusion injury ,sepsis and diabetes .Mitochondrial become an attractive target for drug transporters strategy and therapeutic targets for neurodegeneration .Although the molecular mechanisms responsible for mitochondria media‐ted disease processes are not fully elucidated yet ,the oxidative stress appears to be critical .Accordingly ,strategies are being de‐veloped for the targeted delivery of antioxidants to mitochondria .The prospect of development of mitochondrial targeted drugs with anti‐oxidative stress protection is tempting .Mitochondrial targeting antioxidants were the antioxidant drugs which took mi‐tochondria as the target site .In this review ,weintroduced the conception and classification of mitochondrial targeted antioxidants and the research progress of disease treatment by mitochondrial targeted antioxidants .
