Inhibitory activity ofα-glucosidase in four starfishes
10.3969/j.issn.1006-0111.2014.04.012
- VernacularTitle:4种海星的α-葡萄糖苷酶抑制活性研究
- Author:
Gaiyun ZHANG
1
;
Lin FAN
;
Zhonghai HOU
;
Yubian ZHANG
;
Yanliu YANG
Author Information
1. 国家海洋局第三海洋研究所生物遗传资源重点实验室
- Keywords:
starfish;
Asterias rollestoni;
glucose tolerance;
α-glucosidase;
alloxan
- From:
Journal of Pharmaceutical Practice
2014;(4):284-287
- CountryChina
- Language:Chinese
-
Abstract:
Objective To search for starfishes with hopoglycemic activity and orientate the bioactive fractions .Methods Firstly, the crude extracts of four starfishes were subjected to oral glucose tolerance test on normal and diabetic mice .And then the in vitroα-glucosidase activity assay was introduced to confirm the bioactive fractions .Results The crude extract of Asterias rollestoni could lower the blood glucose of normal and diabetic mice after 0.5 h and 1 h.Furthermore, its n-BuOH fraction exhibited potent α-glucosidase inhibitoary activity .Conclusion The n-BuOH extract of Asterias rollestoni had a potent α-glucosidase inhibitoary activity .
