Prepraation and detection of in vitro dis solution of if nasteridec oated dispre sible tablets
10.3969/j.issn.1006-0111.2014.04.009
- VernacularTitle:非那雄胺包衣分散片的制备及体外溶出度测定
- Author:
Jun QIU
1
;
Yanru XU
;
Qiping ZENG
;
Guixiang ZHONG
;
Jianming ZHU
;
Hongtao SONG
Author Information
1. 南京军区鼓浪屿疗养院药械科
- Keywords:
finasteride;
dispersible tablets;
film coating;
orthogonal experiment;
dissolution
- From:
Journal of Pharmaceutical Practice
2014;(4):273-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To optimize the prescription and preparation technology of finasteride dispersible tablets .Methods Wet granulation technique was applied to optimize the formulation and technology of finasteride tablets .Results The formulation of fi-nasteride tablets was that microcrystalline cellulose and lactose acts as diluent , 5% of low-substituted hydroxypropyl cellulose acts as disintegrant , 5%of povidone in alcohol water mixture acts as adhesive and 15%of opadry 85 G type acts as coating solution .The per-centage of dissolution was more than 90%in 45 miniutes.Conclusion The self-made finasteride tablets had stable quality , reliable process and were suitable for industrialized mass production .
