The role of regulatory T cells in immune dysfunction during sepsis

Author: Chao CAO ¹ ; Tao MA ; Yan-Fen CHAI ; Song-Tao SHOU
Author Information

1. Emergency Department
Publication Type:Journal Article
Keywords: Regulatory T cells; Sepsis; Immune dysfunction
From: World Journal of Emergency Medicine 2015;6(1):5-9
CountryChina
Language:English
Abstract: BACKGROUND: Although regulatory T cells (Tregs) are key to the maintenance of immunologic homeostasis and tolerance, little is known about Treg-mediated immunosuppression in the stage of sepsis. This article aimed to review the current literature on the role of Tregs in the pathophysiology of septic response, attempting to investigate the role of Tregs in immune dysfunction during sepsis. DATA SOURCES: A literature search was conducted in January 2014 using the China National Knowledge Infrastructure and PubMed. Articles on the role of Tregs in immune dysfunction during sepsis were identified. RESULTS: The identified articles indicated that Treg levels can be used for the assessment of the course of sepsis. The inhibition of Treg activity can promote the recovery of immune function. CONCLUSION: Since the mechanism of Tregs is complex during the sepsis, more studies are needed.