A new alkaloid from Rehmanniae Radix Preparata
10.16438/j.0513-4870.2019-0716
- VernacularTitle:九蒸九晒熟地黄中的一个新生物碱
- Author:
Jin-jin LÜ
1
;
Jing-ke ZHANG
1
;
Bei-bei ZHANG
1
;
Juan-juan LIU
1
;
Meng LI
1
;
Jing-ya SHI
1
;
Deng-hui ZHU
1
;
Hang YANG
2
;
Xiao-ke ZHENG
1
;
Wei-sheng FENG
1
Author Information
1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Diagnosis by Henan and Education Ministry of P. R. China, Zhengzhou 450046, China
2. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
- Publication Type:Research Article
- Keywords:
Rehmanniae Radix Preparata;
chemical compositions;
alkaloids;
NRK-52e cells;
RTCA
- From:
Acta Pharmaceutica Sinica
2020;55(2):289-293
- CountryChina
- Language:Chinese
-
Abstract:
The chemical constituents of Rehmanniae Radix Preparatawere prepared according to the traditional method of "jiu zheng jiu shai" and investigated using multiple chromatographic methods. Six alkaloids were isolated and their structures were elucidated from spectral data and physicochemical properties, as follows: rehmanniae alkaloid A (4-{[(5-O-á-D-galactopyranosyloxy)methyl]-1H-pyrrole-2-carbaldehyde-1-yl}butyric acidmethyl ester) (1), baimantuoluoamide B (2), capparisine C (3), harman-3-carboxylic acid (4), (2S)-1-[2-(furan-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carboxylate (5), and 1-[2-(furan-2-yl)-2-oxoethyl]pyrrolidin-2-one (6). Among them, compound 1 is a new alkaloid. Compounds 2-6 were newly isolated from Rehmannia glutinosa Libosch.The effect of compounds 1-6 on NRK-52e cell injury induced by LPS was investigated. The results show that compounds 1-3 exhibit protective effects against LPS-induced damage to NRK-52e cells.
