Adenovirus-induced Hemophagocytic Lymphohistiocytosis in a Previously Healthy Boy: A Case Report and Literature Review
10.15264/cpho.2016.23.2.179
- Author:
Yo Han SEO
1
;
Ye Jee SHIM
;
Heung Sik KIM
;
Hee Joung LEE
;
Dong Seok JEON
;
Ho Joon IM
Author Information
1. Department of Pediatrics, Keimyung University School of Medicine and Dongsan Medical Center, Daegu, Korea. yejeeshim@dsmc.or.kr
- Publication Type:Case Report
- Keywords:
Adenovirus;
Hemophagocytic lymphohistiocytosis;
Immunocompetent;
Infection-associated hemophagocytic syndrome
- MeSH:
Abdominal Pain;
Adenoviridae;
Anti-Bacterial Agents;
Ascites;
Child;
Child, Preschool;
Cyclosporine;
Dexamethasone;
Diarrhea;
Disseminated Intravascular Coagulation;
Drug Therapy;
Edema;
Etoposide;
Fever;
Humans;
Lymphohistiocytosis, Hemophagocytic;
Male;
Methods;
Pleural Effusion;
Recurrence;
Splenomegaly;
Vomiting
- From:Clinical Pediatric Hematology-Oncology
2016;23(2):179-183
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 3-year-old previously healthy boy was admitted because of a 1-week history of fever, abdominal pain, vomiting, and diarrhea. The initial laboratory tests showed hepatic dysfunction with disseminated intravascular coagulation. There was a large amount of pleural effusion, periportal edema, minimal ascites, and splenomegaly. He was initially managed with broad spectrum antibiotics with transfusion. Despite 2 days of treatment, the fever persisted and the results of the laboratory tests had worsened. Bacterial cultures from the blood, urine, pleural effusion, and ascites were all negative. He was finally diagnosed with hemophagocytic lymphohistiocytosis (HLH) based on the diagnostic criteria. Adenovirus was detected in the initial diarrhea and nasal swab specimens using polymerase chain reaction-based method. One year after chemotherapy with dexamethasone, cyclosporine, and etoposide, he is now healthy without evidence of disease recurrence. This is the first Korean case report of adenovirus-induced HLH in a previously healthy child.
