Effect of Amyloid Deposition in PET on Hippocampal Metabolism in Amnestic-Mild Cognitive Impairment : Pilot Study
- Author:
Giok KIM
1
;
Young Min LEE
;
Je Min PARK
;
Byung Dae LEE
;
Eun Soo MOON
;
Hee Jeong JEONG
;
Soo Yeon KIM
;
Kang Yoon LEE
;
Hwagyu SUH
;
Hak Jin KIM
;
Kyoungjune PAK
;
Chi Woong MUN
;
Ji Hoon KIM
;
Young In CHUNG
Author Information
1. Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
- Publication Type:Original Article
- Keywords:
Amyloid beta;
Hippocampal metabolism;
Amnestic mild cognitive impairment
- MeSH:
Amyloid;
Cognition Disorders;
Metabolism;
Pilot Projects;
Plaque, Amyloid;
Positron-Emission Tomography
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2019;25(3):251-256
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Most studies of hippocampal metabolism(HM) in amnestic mild cognitive impairment(aMCI) gave inconsistent results. Our objective was to evaluate the effect of amyloid-beta(Aβ) status on hippocampal metabolism in aMCI.METHODS: Overall, 23 aMCI underwent three-dimensional magnetic resonance imaging(MRI), ¹⁸F-fluorodeoxyglucose-positron emission tomography(¹⁸FDG-PET) and ¹⁸F-Fluorbetaben amyloid positron emission tomography (amyloid-PET). According to Aβ status on amyloid PET, 23 aMCI were classified as either Aβ+aMCI(N=13) or Aβ−aMCI(N=10). The primary outcome was HM using ¹⁸FDG-PET and we investigate the difference on HM between Aβ+aMCI and Aβ−aMCI using analysis of variance(ANOVA) model, after controlling hippocampal volume.RESULTS: We found that HM was more decreased in Aβ+aMCI than Aβ−aMCI. This result was not changed after controlling hippocampal volume.CONCLUSION: Our findings suggest that Aβ+ is associated with decreased HM, regardless of hippocampal volume, in aMCI.
