The Association of Plasma Inflammatory Cytokines with Dementia and Mild Cognitive Impairment
- Author:
Kyung Hoon SON
1
;
Su Jeong SEONG
;
Won Joon LEE
;
Jae Yeon HWANG
;
Jae Hyun HAN
;
Yeong Ju JEON
;
Chang Hwan HAN
Author Information
1. Department of Psychiatry, Kangdong Sacred Heart Hospital, Seoul, Korea. seongsj01@gmail.com
- Publication Type:Original Article
- Keywords:
Dementia;
Mild cognitive impairment;
Aging;
Cytokine;
Tumor necrosis factor-alpha;
Insulin-like growth factor-I;
Interleukin-6
- MeSH:
Aged;
Aging;
Cytokines;
Dementia;
Diagnosis;
Humans;
Insulin-Like Growth Factor I;
Interleukin-6;
Mild Cognitive Impairment;
Necrosis;
Plasma;
Tumor Necrosis Factor-alpha
- From:
Journal of the Korean Society of Biological Therapies in Psychiatry
2019;25(1):28-35
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study was to investigate the association of plasma levels of inflammatory cytokines with dementia and mild cognitive impairment.METHODS: We compared serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin-6(IL-6), and insulin-like growth factor-1(IGF-I) in patients with dementia(n=8), mild cognitive impairment(MCI, n=15) and normal elderly (n=14). The diagnosis of dementia was made by the Diagnostic Statistical Manual of Mental Disorders-4th edition (DSM-IV). MCI was diagnosed based on the criteria of the National Institute of Aging and Alzheimer Association(NIA-AA) working group.RESULTS: When compared with normal controls, the levels of TNF-alpha and IL-6 were increased and level of IGF-I was decreased in MCI and dementia. Higher levels of TNF-alpha and IL-6 and lower level of IGF-I were also associated with increased age. However, when adjusted for age, the association between diagnosis and TNF-alpha, Il-6 and IGF-I was not significant.CONCLUSION: The difference in plasma levels of inflammatory cytokines in dementia and MCI may be associated with aging.
